I was asked to explain what I considered to be information when discussing genetic activity in a cell.
There are two different definitions of information where cellular activity is concerned.
The first, and most common, is stochastic information, or the random reproduction of bits of RNA or DNA in some mutations.
The second is meaningful, or useful information, and should not be confused with stochastic information.
Random addition of bits mean nothing to the cell. It cannot use them and dissembles them. When they are accidental replications of entire chromosomes, we have something called trisomy which results in such things as Down's Syndrome and, depending on the chromosome duplicated, a variety of lethal results.
Meaningful information would be genetic material which is new to the cell which is able to be incorporated into the genetic makeup and be used by the cell in some fashion.
What happens in the vast (well over 99%) of 'evolutionary' mutations is a loss of meaningful information due to the malformation or missing of a portion of the genetic code. A protein may fold less specifically, thus no longer providing a binding site for something else (this is what antibiotic resistance is).
We have NEVER seen a new sort of protein (one not originally in the cell) made by a cell, much less used by one. And it is this which evolution depends on.